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DOLGIT gel 50g 5%
Active ingredients
Ibuprofen
Release form
Gel
Composition
100 g of gel contains 5 g of the active substance ibuprofen; excipients: isopropanol, dimethylhydroxymethyldioxolan (Solketal), poloxamer a;b;c = 101;56;101 (Poloxamer 407, Pluronic F 127), medium-cap triglycerides (Migliol 812), purified water, lavender oil, orange blossom oil (nerola oil).
Pharmacological effect
The drug has a local analgesic and anti-inflammatory effect. Suppresses the production of inflammatory mediators. It selectively blocks cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin, prostacyclin and thromboxane. The analgesic effect is most pronounced in inflammatory pain: the drug weakens the pain syndrome with pain at rest and during movement; reduces morning stiffness and swelling of joints; helps to increase the volume of movements. In addition to the anti-inflammatory effect, ibuprofen reduces platelet aggregation at the site of inflammation, as well as leukocyte migration and the release of lysosomal enzymes in the inflammatory zone.
Pharmacokinetics
When applying the gel to the skin, ibuprofen penetrates deeper tissues (subcutaneous tissue, muscles, joints, synovial fluid) and reaches therapeutic concentrations in them. The therapeutic effect in the area of application is achieved by direct distribution through the skin into the target tissue. It is detected in small amounts in blood plasma. With the recommended method of application, the concentration in the synovial fluid is about 2 micrograms /ml.
Indications
– Inflammatory and degenerative diseases of the musculoskeletal system: articular syndrome with exacerbation of gout, arthritis (rheumatoid, psoriatic, gouty), shoulder periarthritis, ankylosing spondylitis (Bechterev’s disease), deforming osteoarthritis, osteochondrosis with radicular syndrome, sciatica, tendinitis, tendovaginitis, bursitis, lumbago, sciatica.- Muscle pain (myalgia) of rheumatic and non-rheumatic origin.- Injuries (sports, industrial, household, etc.) without violating the integrity of the skin (dislocations, sprains or tears of muscles and ligaments, bruises, post-traumatic swelling of soft tissues, etc.).
Contraindications
Hypersensitivity to ibuprofen, the components of the drug and other NSAIDs; bronchial asthma, urticaria, rhinitis, provoked by taking acetylsalicylic acid; wet dermatoses, eczema, violations of the integrity of the skin at the site of application of the gel, including infected wounds and abrasions; pregnancy (III trimester), children under 12 years of age.
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